Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk.

@article{Ambrosone1995CytochromePA,
  title={Cytochrome P4501A1 and glutathione S-transferase (M1) genetic polymorphisms and postmenopausal breast cancer risk.},
  author={Christine B. Ambrosone and Jo L Freudenheim and Saxon Graham and James Arthur Robert Marshall and John E. Vena and John R. Brasure and Rosemary Laughlin and Takuma Nemoto and A. Michalek and Anita M. Harrington},
  journal={Cancer research},
  year={1995},
  volume={55 16},
  pages={3483-5}
}
Polycyclic aromatic hydrocarbons, possible human breast carcinogens, are metabolized by cytochrome P4501A1 (CYP1A1) and glutathione S-transferase (GSTM1). A CYP1A1 polymorphism (isoleucine to valine substitution in exon 7) or the null allele for GSTM1 may affect the mutagenic potential of polycyclic aromatic hydrocarbons. We examined polymorphisms in GSTM1 and CYP1A1 in relation to breast cancer risk. Included were 216 postmenopausal Caucasian women with incident breast cancer and 282 community… CONTINUE READING
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