Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.

  title={Cytochrome P450 promiscuity leads to a bifurcating biosynthetic pathway for tanshinones.},
  author={Juan Guo and Xiaohui Ma and Yuan Cai and Yongqiang Ma and Zhilai Zhan and Yongjin J Zhou and Wujun Liu and Mengxin Guan and Junxing Yang and Guanghong Cui and Li-ping Kang and Lei Yang and Ye Shen and Jin-fu Tang and Huixin Lin and Xiaojing Ma and Baolong Jin and Zhenming Liu and Reuben J Peters and Zongbao K Zhao and Luqi Huang},
  journal={The New phytologist},
  volume={210 2},
Cytochromes P450 (CYPs) play a key role in generating the structural diversity of terpenoids, the largest group of plant natural products. However, functional characterization of CYPs has been challenging because of the expansive families found in plant genomes, diverse reactivity and inaccessibility of their substrates and products. Here we present the characterization of two CYPs, CYP76AH3 and CYP76AK1, which act sequentially to form a bifurcating pathway for the biosynthesis of tanshinones… CONTINUE READING
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