Cytochrome P450 pharmacogenetics in African populations: implications for public health.

@article{Dandara2014CytochromePP,
  title={Cytochrome P450 pharmacogenetics in African populations: implications for public health.},
  author={Collet Dandara and Marelize Swart and Bafokeng Mpeta and Ambroise Wonkam and Collen Masimirembwa},
  journal={Expert opinion on drug metabolism & toxicology},
  year={2014},
  volume={10 6},
  pages={769-85}
}
INTRODUCTION Africa harbors a disproportionate burden of disease when taking into account the triple challenge caused by HIV/AIDS, tuberculosis (TB) and malaria, against a backdrop of an increasing burden of noncommunicable diseases. More than 80% of therapeutic drugs used in the management of these diseases/conditions are metabolized by CYP enzymes that exhibit genetic polymorphisms. AREAS COVERED There is variability in the expression and activities of CYPs resulting in interindividual… CONTINUE READING
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