Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism.

Abstract

AIMS The plasma clearance of theobromine (TB; 3,7-dimethylxanthine) is known to be induced in cigarette smokers. To determine whether TB may serve as a model substrate for cytochrome P450 (CYP) 1A2, or possibly other isoforms, studies were undertaken to identify the individual human liver microsomal CYP isoforms responsible for the conversion of TB to its… (More)

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@article{Gates1999CytochromePI, title={Cytochrome P450 isoform selectivity in human hepatic theobromine metabolism.}, author={Sabrina N Gates and J. O. Miners}, journal={British journal of clinical pharmacology}, year={1999}, volume={47 3}, pages={299-305} }