Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification.

@article{Lu2003CytochromePI,
  title={Cytochrome P450 in vitro reaction phenotyping: a re-evaluation of approaches used for P450 isoform identification.},
  author={A. Y. Lu and Regina W. Wang and J. Lin},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2003},
  volume={31 4},
  pages={
          345-50
        }
}
Marker substrates, chemical inhibitors, and inhibitory antibodies are important tools for the identification of cytochrome P450 (P450) isoform responsible for the metabolism of therapeutic agents in vitro. In view of the versatile and nonspecific nature of P450 enzymes, many of the marker substrates and chemical inhibitors used for P450 in vitro reaction phenotyping are isoform selective but not specific. Recently, the use of marker substrate and chemical inhibitors in CYP2D6 in vitro reaction… Expand
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