Cytochrome P450 in rat astrocytes in vivo and in vitro: intracellular localization and induction by phenytoin.

@article{Kempermann1994CytochromePI,
  title={Cytochrome P450 in rat astrocytes in vivo and in vitro: intracellular localization and induction by phenytoin.},
  author={Gerd Kempermann and Rolf Knoth and Peter J. Gebicke-haerter and Barbara Stolz and Benedikt Volk},
  journal={Journal of neuroscience research},
  year={1994},
  volume={39 5},
  pages={
          576-88
        }
}
Cytochrome P450IIB1,2 (nomenclature according to Nelson et al., DNA Cell Biol 12:1-51, 1993 and Volk et al., Neuroscience 42:215-235, 1991) immunoreactivity (P450-IR) is associated with astrocytes both in vivo and in vitro. Although they are unevenly distributed throughout the brain with a preference for phylogenetically elder parts, no significant differences between astrocytes prepared from different brain regions were observed in astrocyte cultures. The percentage of strongly immunoreactive… CONTINUE READING

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