Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients

@article{Onizuka2011CytochromePG,
  title={Cytochrome P450 genetic polymorphisms influence the serum concentration of calcineurin inhibitors in allogeneic hematopoietic SCT recipients},
  author={Makoto Onizuka and Naoto Kunii and Masako Toyosaki and Shinichiro Machida and Daisuke Ohgiya and Yoko Ogawa and Hideaki Kawada and Hidetoshi Inoko and Kimiko Ando},
  journal={Bone Marrow Transplantation},
  year={2011},
  volume={46},
  pages={1113-1117}
}
Calcineurin inhibitors are necessary as immunosuppressants during hematopoietic SCT (HSCT) to prevent alloreactivity, but have unfortunate toxicities. So, we investigated the association of gene polymorphisms with the initial calcineurin inhibitor concentration and the subsequent drug dose from day 1 to day 28 among patients who underwent HSCT at a single institution. We analyzed 58 serial cases of Japanese patients receiving GVHD prophylaxis with CsA (21 cases) or tacrolimus (37 cases). We… CONTINUE READING
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Multicenter FK506 Liver Study Group. A comparison of tacrolimus (FK 506) and cyclosporine for immunosuppression in liver transplantation

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  • N Engl J Med
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