Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan).

@article{Baldwin2006CytochromePG,
  title={Cytochrome P450 gene induction in rats ex vivo assessed by quantitative real-time reverse transcriptase-polymerase chain reaction (TaqMan).},
  author={Sandra J Baldwin and Jo L. Bramhall and Charlotte A Ashby and Lin Lin Yue and Paul R. Murdock and Steven R Hood and Andrew D Ayrton and Stephen E. Clarke},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2006},
  volume={34 6},
  pages={
          1063-9
        }
}
Drug-induced changes in expression of cytochrome P450 (P450) genes are a significant issue in the preclinical development of pharmaceuticals. For example, preclinically, P450 induction can affect safety studies by reducing the systemic exposure of a compound undergoing toxicological evaluation, thus limiting the exposure that can be safely investigated in patients. Therefore, the induction potential of candidate drugs has been studied as part of the drug development process, typically using… CONTINUE READING

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