Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold.

@article{Matsuda2016CytochromePF,
  title={Cytochrome P450 for Citreohybridonol Synthesis: Oxidative Derivatization of the Andrastin Scaffold.},
  author={Yudai Matsuda and Zhiyang Quan and Takaaki Mitsuhashi and Chang Li and Ikuro Abe},
  journal={Organic letters},
  year={2016},
  volume={18 2},
  pages={296-9}
}
A biosynthetic gene cluster similar to that for andrastin A (1) was discovered in Emericella variecolor NBRC 32302. Ctr-P450, a cytochrome P450 uniquely present in the cluster, was coexpressed with the andrastin A biosynthetic genes, leading to the production of the antifeedant agent citreohybridonol (4), along with four new andrastin derivatives. The… CONTINUE READING