Cytochrome P450 epoxygenases as EDHF synthase(s).

  title={Cytochrome P450 epoxygenases as EDHF synthase(s).},
  author={Ingrid Fleming},
  journal={Pharmacological research},
  volume={49 6},
The metabolism of arachidonic acid by cytochrome P450 (CYP) epoxygenases generates epoxyeicosatrienoic acids (EETs) which affect numerous cellular process including Ca(2+) signaling and the activity of Ca(2+)-dependent K(+) channels. The expression of the CYP epoxygenase(s) that generate EETs in endothelial cells is not constitutive but is determined by a number of physical (fluid shear stress and cyclic stretch) and pharmacological stimuli which also affect responses attributed to an… CONTINUE READING