Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.

@article{Watanabe2007CytochromePE,
  title={Cytochrome P450 enzymes involved in the metabolism of tetrahydrocannabinols and cannabinol by human hepatic microsomes.},
  author={Kazuhito Watanabe and Satoshi Yamaori and Tatsuya Funahashi and Toshiyuki Kimura and Ikuo Yamamoto},
  journal={Life sciences},
  year={2007},
  volume={80 15},
  pages={1415-9}
}
In this study, tetrahydrocannabinols (THCs) were mainly oxidized at the 11-position and allylic sites at the 7alpha-position for Delta(8)-THC and the 8beta-position for Delta(9)-THC by human hepatic microsomes. Cannabinol (CBN) was also mainly metabolized to 11-hydroxy-CBN and 8-hydroxy-CBN by the microsomes. The 11-hydroxylation of three cannabinoids by… CONTINUE READING