Cytochrome P450 enzymes and genotype-guided drug therapy.

@article{Roederer2009CytochromePE,
  title={Cytochrome P450 enzymes and genotype-guided drug therapy.},
  author={Mary W. Roederer},
  journal={Current opinion in molecular therapeutics},
  year={2009},
  volume={11 6},
  pages={632-40}
}
The cytochome P450 enzyme system is responsible for the metabolism of xenobiotics, including > 75% of commonly prescribed medications. Many of the cytochrome enzymes exhibit polymorphic genotypes, partly accounting for the variations observed in individual drug responses. Recent advances in the understanding of functional alleles of cytochrome P450 enzymes have changed the use of medications. Improvements in drug efficacy and the prevention of toxicity, as well as improvements in clinical drug… CONTINUE READING

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