Cytochrome P450 enzyme polymorphisms and treatment-related ovarian toxicity in patients with SLE

Abstract

BACKGROUND Treatment with pulse intravenous cyclo­ phosphamide is considered a standard therapy for patients with systemic lupus erythema­ tosus (SLE). Potential risks associated with treatment include an increased risk of ovarian toxicity, infection, and hemorrhagic cystitis. Ovarian toxicity is a major concern in young female patients receiving treatment… (More)
DOI: 10.1038/ncprheum0574

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