Cytochrome P450 destruction by quinones: comparison of effects in rat and human liver microsomes.

Abstract

Exposure to benzene was recently reported to lower the cytochrome P450 (CYP) content in phenobarbital-pretreated rats in vivo (Gut et al., Environ. Health Perspect. 104 (1996) 1211-1218). This study followed the ability of quinonic benzene metabolites (catechol, hydroquinone, and benzoquinone) to destroy CYP in liver microsomes from rats pretreated with… (More)

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Cite this paper

@article{Souek1999CytochromePD, title={Cytochrome P450 destruction by quinones: comparison of effects in rat and human liver microsomes.}, author={Přemysl Sou{\vc}ek}, journal={Chemico-biological interactions}, year={1999}, volume={121 3}, pages={223-36} }