Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics.

@article{Rittle2010CytochromePC,
  title={Cytochrome P450 compound I: capture, characterization, and C-H bond activation kinetics.},
  author={Jonathan Rittle and Michael T Green},
  journal={Science},
  year={2010},
  volume={330 6006},
  pages={
          933-7
        }
}
Cytochrome P450 enzymes are responsible for the phase I metabolism of approximately 75% of known pharmaceuticals. P450s perform this and other important biological functions through the controlled activation of C-H bonds. Here, we report the spectroscopic and kinetic characterization of the long-sought principal intermediate involved in this process, P450 compound I (P450-I), which we prepared in approximately 75% yield by reacting ferric CYP119 with m-chloroperbenzoic acid. The Mössbauer… CONTINUE READING

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