Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?

@article{Meesters2009CytochromePA,
  title={Cytochrome P450-catalysed arene-epoxidation of the bioactive tea tree oil ingredient p-cymene: indication for the formation of a reactive allergenic intermediate?},
  author={Roland J W Meesters and Mike Duisken and Juliane Hollender},
  journal={Xenobiotica; the fate of foreign compounds in biological systems},
  year={2009},
  volume={39 9},
  pages={663-71}
}
1. The cytochrome P450-mediated metabolism of the tea tree oil ingredient p-cymene (p-isopropyltoluene) was studied by the application of in vitro enzymatic assays using different recombinant human cytochrome P450 enzymes. 2. In total, four enzymatic products were identified by gas chromatography-mass spectrometry. The enzymatic products identified were… CONTINUE READING