Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer

  title={Cytochrome P450 aromatase gene (CYP19) expression in gastric cancer},
  author={Masao Izawa and Masashi Inoue and Mitsuhiko Osaki and Hisao Ito and Tasuku Harada and Naoki Terakawa and Masahide Ikeguchi},
  journal={Gastric Cancer},
The secretion of biologically active estrogen through the conversion of circulating precursor androgens has been suggested to play important roles in the pathophysiology of estrogen-dependent carcinomas. In the present study, we examined aromatase expression in gastric carcinoma. Nineteen specimens of gastric carcinoma were obtained from Japanese patients at the Department of Surgery, Tottori University Hospital, Japan. Nontumoral tissues adjacent to the carcinoma were also available for… CONTINUE READING