Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics

@article{Rittle2010CytochromePC,
  title={Cytochrome P450 Compound I: Capture, Characterization, and C-H Bond Activation Kinetics},
  author={Jonathan Rittle and Michael T Green},
  journal={Science},
  year={2010},
  volume={330},
  pages={933 - 937}
}
  • Jonathan Rittle, Michael T Green
  • Published 2010
  • Medicine, Chemistry
  • Science
  • The Power Behind P450 Drugs, toxins and a range of metabolic substrates are detoxified in the liver by family of iron-containing enzymes called cytochrome P450. The iron component transfers oxygen to compounds that are often highly resistant to chemical reaction, but we know very little about the mechanism of this vital detoxification process. Rittle and Green (p. 933; see the Perspective by Sligar) have managed to capture the P450 reaction intermediate by freezing a solution of the enzyme as… CONTINUE READING

    Paper Mentions

    Citations

    Publications citing this paper.
    SHOWING 1-10 OF 759 CITATIONS, ESTIMATED 50% COVERAGE

    Spectroscopic studies of the cytochrome P450 reaction mechanisms.

    FILTER CITATIONS BY YEAR

    2010
    2020

    CITATION STATISTICS

    • 10 Highly Influenced Citations

    • Averaged 54 Citations per year from 2018 through 2020

    References

    Publications referenced by this paper.
    SHOWING 1-10 OF 39 REFERENCES