Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.

  title={Cytochrome P450 CYP3A4/5 expression as a biomarker of outcome in osteosarcoma.},
  author={Hassan R Dhaini and Dafydd Gareth Thomas and Thomas J. Giordano and Timothy D. Johnson and Janet Sybil Biermann and Kirsten M Leu and Paul F. Hollenberg and Laurence H. Baker},
  journal={Journal of clinical oncology : official journal of the American Society of Clinical Oncology},
  volume={21 13},
PURPOSE Osteosarcoma, the most common pediatric primary bone tumor, is an aggressive malignancy with a tendency for early pulmonary metastasis. A reliable biomarker to predict clinical outcome at diagnosis has not yet been identified. To date, pathological review of neoadjuvant chemotherapy-induced necrosis is the most useful determinant of which patients are likely to develop metastatic disease. There is a clinical need to identify patients who will benefit from more aggressive preoperative… CONTINUE READING