Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population

@article{Kocaba2002CytochromePC,
  title={Cytochrome P450 CYP1B1 and catechol O-methyltransferase (COMT) genetic polymorphisms and breast cancer susceptibility in a Turkish population},
  author={Neslihan Ayg{\"u}n Kocabaş and Semra Şardaş and Suzanne Cholerton and Ann K Daly and Ali Esat Karakaya},
  journal={Archives of Toxicology},
  year={2002},
  volume={76},
  pages={643-649}
}
Epidemiological studies indicate that most risk factors for breast cancer are related to reproductive and hormonal factors. Estrogen has been proposed to trigger breast cancer development via an initiating mechanism involving its metabolite, catechol estrogen (CE). Because of the important role of cytochrome P450 1B1 (CYP1B1) and catechol O-methyltransferase (COMT) in mammary estrogen and carcinogen metabolism, we examined the CYP1B1 and COMT genes to determine whether genetic variations could… CONTINUE READING
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