Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc.

@article{Lu2012CytochromeP3,
  title={Cytochrome P450 3A5 plays a prominent role in the oxidative metabolism of the anti-human immunodeficiency virus drug maraviroc.},
  author={Yanhui Lu and Craig W Hendrix and Namandj{\'e} N Bumpus},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={2012},
  volume={40 12},
  pages={
          2221-30
        }
}
Maraviroc is an anti-human immunodeficiency virus drug that acts by blocking viral entry into target cells. With use of ultra-performance liquid chromatography-mass spectrometry several monooxygenated, dioxygenated, and glucuronidated metabolites of maraviroc were identified both in vitro and in vivo. Characterization of the enzymes involved in the production of these metabolites determined that cytochrome P450 3A5 was the principal enzyme responsible for the formation of an abundant metabolite… CONTINUE READING

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