Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.

@article{Leskel2007CytochromeP3,
  title={Cytochrome P450 3A5 is highly expressed in normal prostate cells but absent in prostate cancer.},
  author={Susanna Leskel{\"a} and Emiliano Honrado and Cristina Montero-Conde and Iňigo Landa and Alberto Casc{\'o}n and Roc{\'i}o Let{\'o}n and Paloma Talavera and Jos{\'e} Manuel C{\'o}zar and Adriana Concha and Mercedes Robledo and Cristina Rodr{\'i}guez-Antona},
  journal={Endocrine-related cancer},
  year={2007},
  volume={14 3},
  pages={645-54}
}
Testosterone is essential for the growth and function of the luminal prostate cells, but it is also critical for the development of prostate cancer, which in the majority of the cases derives from luminal cells. Cytochrome P450 3A (CYP3A) enzymes hydroxylate testosterone and dehydroepiandrosterone to less active metabolites, which might be the basis for the association between CYP3A polymorphisms and prostate cancer. However, it is unknown whether the CYP3A enzymes are expressed at relevant… CONTINUE READING

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