Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus.

@article{Pucci2003CytochromeP2,
  title={Cytochrome P450 2J2 polymorphism in healthy Caucasians and those with diabetes mellitus.},
  author={Laura Pucci and Daniela Lucchesi and Vera Chirulli and Giuseppe Penno and Inger Johansson and Pier Giovanni Gervasi and Stefano Del Prato and Vincenzo Longo},
  journal={American journal of pharmacogenomics : genomics-related research in drug development and clinical practice},
  year={2003},
  volume={3 5},
  pages={355-8}
}
OBJECTIVE Cytochrome P450 (CYP) 2J2 plays an important role in the biosynthesis of the biologically active cis-epoxyeicosatrienoic acids. An allelic variant named CYP2J2*6, which encodes an enzyme that is almost inactive in the metabolism of arachidonic acid, has recently been described. We investigated the frequency of the CYP2J2*6 variant in a Caucasian population and the relationship between this polymorphism and the development of micro- and macrovascular complications and hypertension in… CONTINUE READING