Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats.

@article{Ye2012CytochromeP2,
  title={Cytochrome P450 2E1 inhibition prevents hepatic carcinogenesis induced by diethylnitrosamine in alcohol-fed rats.},
  author={Qinyuan Ye and Fuzhi Lian and P. Chavez and J. Chung and W. Ling and H. Qin and H. Seitz and X. Wang},
  journal={Hepatobiliary surgery and nutrition},
  year={2012},
  volume={1 1},
  pages={
          5-18
        }
}
  • Qinyuan Ye, Fuzhi Lian, +5 authors X. Wang
  • Published 2012
  • Medicine
  • Hepatobiliary surgery and nutrition
  • Chronic alcohol ingestion increases hepatic cytochrome P450 2E1 (CYP2E1), which is associated with hepatocarcinogenesis. We investigated whether treatment with chlormethiazole (CMZ), a CYP2E1 inhibitor, protects against alcohol-associated hepatic carcinogenesis in rats. Rats were fed either an ethanol liquid diet or a non-ethanol liquid diet, with or without CMZ for one and ten months. A single intraperitoneal injection of diethylnitrosamine (DEN, 20 mg/kg) was given to initiate hepatic… CONTINUE READING
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