Cytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.

@article{Lobello2010CytochromeP2,
  title={Cytochrome P450 2D6 phenotype predicts antidepressant efficacy of venlafaxine: a secondary analysis of 4 studies in major depressive disorder.},
  author={Kasia Lobello and Sheldon H. Preskorn and Christine J. Guico-Pabia and Qin Jiang and Jeffrey Paul and Alice I. Nichols and Albena Patroneva and Philip T Ninan},
  journal={The Journal of clinical psychiatry},
  year={2010},
  volume={71 11},
  pages={
          1482-7
        }
}
  • Kasia Lobello, Sheldon H. Preskorn, +5 authors Philip T Ninan
  • Published in
    The Journal of clinical…
    2010
  • Psychology, Medicine
  • INTRODUCTION Venlafaxine, a serotonin-norepinephrine reuptake inhibitor antidepressant, is metabolized primarily by the cytochrome P450 2D6 enzyme into O-desmethylvenlafaxine (ODV). The ODV/venlafaxine ratio can be used to distinguish between extensive metabolizers (EMs) and poor metabolizers (PMs). OBJECTIVES To determine the relative efficacy and tolerability of venlafaxine in EM vs PM patients with major depressive disorder (MDD). METHOD Data from 4 double-blind, placebo-controlled… CONTINUE READING

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