Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.

  title={Cytochrome P450 2C8 pharmacogenetics: a review of clinical studies.},
  author={Elizabeth B Daily and Christina L Aquilante},
  volume={10 9},
Cytochrome P450 (CYP) 2C8 is responsible for the oxidative metabolism of many clinically available drugs from a diverse number of drug classes (e.g., thiazolidinediones, meglitinides, NSAIDs, antimalarials and chemotherapeutic taxanes). The CYP2C8 enzyme is encoded by the CYP2C8 gene, and several common nonsynonymous polymorphisms (e.g., CYP2C8*2 and CYP2C8*3) exist in this gene. The CYP2C8*2 and *3 alleles have been associated in vitro with decreased metabolism of paclitaxel and arachidonic… CONTINUE READING


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