Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.

@article{Collet2009CytochromeP2,
  title={Cytochrome P450 2C19 polymorphism in young patients treated with clopidogrel after myocardial infarction: a cohort study.},
  author={J. P. Collet and J. C. Hulot and Anna Pe{\~n}a and Eric Villard and J Esteve and Johanne Silvain and Laurent Payot and Delphine Brugier and Guillaume Cayla and Farzin Beygui and Gilbert Bensimon and Christian Funck-Brentano and Gilles Montalescot},
  journal={Lancet},
  year={2009},
  volume={373 9660},
  pages={309-17}
}
BACKGROUND Clopidogrel and low-dose aspirin have become the mainstay oral antiplatelet regimen to prevent recurrent ischaemic events after acute coronary syndromes or stent placement. The frequent genetic functional variant 681 G>A (*2) of cytochrome P450 2C19 (CYP2C19) is an important contributor to the wide variability between individuals of the antiplatelet effect of clopidogrel. We assessed whether the CYP2C19*2 polymorphism affected long-term prognosis of patients who were chronically… CONTINUE READING
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