Cytochrome P450 2C19 genetic polymorphisms in Ugandans

  title={Cytochrome P450 2C19 genetic polymorphisms in Ugandans},
  author={Jun Miura and Celestino Obua and Catherine Abbo and Sunao Kaneko and Tomonori Tateishi},
  journal={European Journal of Clinical Pharmacology},
Sir, Cytochrome P450 (CYP) 2C19 metabolizes a wide variety of drugs [1–6]. A marked inter-individual difference in CYP2C19 enzyme activity has been reported, which can be explained—at least in part—by genetic polymorphisms causing defective (e.g. CYP2C19*2, CYP2C19*3) or increased (CYP2C19*17) activity [1–3, 5–8]. The CYP2C19*2 and CYP2C19*3 alleles account for 100% of the Japanese poor metabolizers (PMs), 83% of Caucasian PMs [7] and 96% of Ethiopian PMs [9]. The impact of the CYP2C19*17… CONTINUE READING