Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts.

  title={Cytochrome P450 2B (CYP2B)-mediated activation of methyl-parathion in rat brain extracts.},
  author={Arnulfo Albores and G Ortega-Mantilla and Adolfo Sierra-Santoyo and Mariano Enrique Cebrian and Jos{\'e} Luis Mu{\~n}oz-S{\'a}nchez and Jose V Calderon-Salinas and Maurizio Manno},
  journal={Toxicology letters},
  volume={124 1-3},
The role of cytochrome P450 (CYP) and the CYP isoform involved in the activation of the widely used pesticide methyl-parathion (MePA) were investigated in rat brain extracts by measuring the effect of different CYP inhibitors on acetylcholinesterase (AChE) inhibition by MePA. Brain extracts provide a useful tool to study the activation mechanisms of organophosphorus compounds (OP) since they contain both the activating enzyme(s) and the molecular target for OP toxicity. As expected, in… CONTINUE READING


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