Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.

@article{Jennings2012CytochromeP1,
  title={Cytochrome P450 1B1 contributes to renal dysfunction and damage caused by angiotensin II in mice.},
  author={Brett L. Jennings and Larry J. Anderson and Anne M. Estes and Fariborz A. Yaghini and Xiao Rong Fang and Jason Porter and Frank J. Gonzalez and William Campbell and Kafait U. Malik},
  journal={Hypertension},
  year={2012},
  volume={59 2},
  pages={348-54}
}
Cytochrome P450 1B1 contributes to the development of angiotensin II-induced hypertension and associated cardiovascular pathophysiology. In view of the critical role of angiotensin II in the kidney, as well as in salt and water homeostasis, and blood pressure regulation, we determined the contribution of cytochrome P450 1B1 to renal dysfunction and injury associated with angiotensin II-induced hypertension in male Cyp1b1(+/+) and Cyp1b1(-/-) mice. Angiotensin II infusion (700 ng/kg per minute… CONTINUE READING
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