Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats

@article{Jennings2014CytochromeP1,
  title={Cytochrome P450 1B1 contributes to increased blood pressure and cardiovascular and renal dysfunction in spontaneously hypertensive rats},
  author={Brett L. Jennings and David E. Montanez and Michael E. May and Anne M. Estes and Xiao Rong Fang and Fariborz A. Yaghini and Alie Kanu and Kafait U. Malik},
  journal={Cardiovascular Drugs and Therapy},
  year={2014},
  volume={28},
  pages={145-161}
}
We investigated the contribution of cytochrome P450 (CYP) 1B1 to hypertension and its pathogenesis by examining the effect of its selective inhibitor, 2,4,3′,5′-tetramethoxystilbene (TMS), in spontaneously hypertensive rats (SHR). Blood pressure (BP) was measured bi-weekly. Starting at 8 weeks, TMS (600 μg/kg, i.p.) or its vehicle was injected daily. At 14 weeks, samples were collected for measurement. TMS reversed increased BP in SHR (207 ± 7 vs. 129 ± 2 mmHg) without altering BP in Wistar… CONTINUE READING
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how can ROS activate MAPK pathways? J Signal Transduct

  • Y Son, Cheong Y-K, +4 authors reactive oxygen species
  • 2011. doi: 10.1155/2011/792639. Cardiovasc Drugs…
  • 2014
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