Corpus ID: 8705753

Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.

@article{Gibson2003CytochromeP1,
  title={Cytochrome P450 1B1 (CYP1B1) is overexpressed in human colon adenocarcinomas relative to normal colon: implications for drug development.},
  author={P. Gibson and J. Gill and Parveen Khan and J. Seargent and S. Martin and P. Batman and J. Griffith and C. Bradley and J. Double and M. Bibby and P. Loadman},
  journal={Molecular cancer therapeutics},
  year={2003},
  volume={2 6},
  pages={
          527-34
        }
}
The cytochrome P450 family of enzymes is involved in the Phase I metabolism of a wide variety of compounds. Although generally involved with detoxification, overexpression of one family member, cytochrome P450 1B1 (CYP1B1), has been associated with human epithelial tumors. As such, CYP1B1 was hypothesized to be a novel target for the development of anticancer therapies. We investigated expression of CYP1B1 protein in 61 human colorectal adenocarcinomas and compared this to that observed in 14… Expand
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