Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study

@article{Hong2003CytochromeP1,
  title={Cytochrome P450 1A2 (CYP1A2) activity, mammographic density, and oxidative stress: a cross-sectional study},
  author={Chi-chen Hong and Bozeng Tang and Venketeshwer Rao and Sanjiv K. Agarwal and Lisa J Martin and David Tritchler and Martin Joel Yaffe and Norman F. Boyd},
  journal={Breast Cancer Research},
  year={2003},
  volume={6},
  pages={R338 - R351}
}
Mammographically dense breast tissue is a strong predictor of breast cancer risk, and is influenced by both mitogens and mutagens. One enzyme that is able to affect both the mitogenic and mutagenic characteristics of estrogens is cytochrome P450 1A2 (CYP1A2), which is principally responsible for the metabolism of 17β-estradiol. In a cross-sectional study of 146 premenopausal and 149 postmenopausal women, we examined the relationships between CYP1A2 activity, malondialdehyde (MDA) levels, and… CONTINUE READING
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