Cytochrome P450 1 family and cancers.

  title={Cytochrome P450 1 family and cancers.},
  author={Ryeo-Eun Go and Kyung-A. Hwang and Kyung-Chul Choi},
  journal={The Journal of steroid biochemistry and molecular biology},
The aryl hydrocarbon receptor (AhR) is a ligand-activated transcriptional factor that dimerizes with aryl hydrocarbon receptor nuclear translocator (ARNT). This complex binds to xenobiotics response element (XREs), and then starts the expressions of downstream genes including cytochrome P450 (CYP) 1 family members: CYP1A1, CYP1A2 and CYP1B1. Role of CYP1 family is involved in the metabolism of endogenous hormones, xenobiotics and drug. The expression of CYP1 family is regulated by estradiol (E2… CONTINUE READING
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