Cytochrome P450 (CYP) mutants and substrate-specificity alterations: segment-directed mutagenesis applied to human CYP1A1.

Abstract

Cytochrome P450 (CYP) enzymes represent a large superfamily that displays extraordinarily diverse substrate specificities. After a concise review about CYPs of the CYP1A subfamily, which plays a crucial role in procarcinogen activation, this paper presents segment-directed mutagenesis. This approach generates a library of random combinatorial mutants… (More)

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Cite this paper

@article{Urbn2001CytochromeP, title={Cytochrome P450 (CYP) mutants and substrate-specificity alterations: segment-directed mutagenesis applied to human CYP1A1.}, author={P{\'e}ter Urb{\'a}n and Antoinette Jobert and Richard M Laine and Denis Pompon}, journal={Biochemical Society transactions}, year={2001}, volume={29 Pt 2}, pages={128-35} }