Cytochrome P450/NADPH-dependent formation of trans epoxides from trans-arachidonic acids.

@article{Roy2004CytochromePF,
  title={Cytochrome P450/NADPH-dependent formation of trans epoxides from trans-arachidonic acids.},
  author={Uzzal Roy and Olivier Loreau and Michael Balazy},
  journal={Bioorganic & medicinal chemistry letters},
  year={2004},
  volume={14 4},
  pages={1019-22}
}
Trans-arachidonic acids (trans-AA) are products of cis-trans isomerization of arachidonic acid by nitrogen dioxide radical (NO(2)), and occur in vivo, but their metabolism is unknown. We found that hepatic microsomes oxidized trans-AA via cytochrome P450/NADPH system to epoxides, which were hydrolyzed by epoxide hydrolase to diols (DiHETEs). 14,15-trans-AA… CONTINUE READING