Cytochrome P-450 metabolism of arachidonic acid.

  • J C Mcgiff
  • Published 1991 in Annual review of pharmacology and toxicology


The cytochrome P-450 pathway of AA metabolism is widely distributed and gives rise to a diversity of products affecting basic biological mechanisms such as vascular reactivity and transport function in critical nephron segments. P-450-AA metabolites may participate in receptor-mediated signal transduction and may act as second messengers. The synthesis of P… (More)