Cytochrome P-450 gene expression in the functional units of the fetal liver.

@article{Chianale1988CytochromePG,
  title={Cytochrome P-450 gene expression in the functional units of the fetal liver.},
  author={J Chianale and C. A. Dvorak and Diana Lee Farmer and Leslie Michaels and J J Gumucio},
  journal={Hepatology},
  year={1988},
  volume={8 2},
  pages={318-26}
}
Hepatocytes of the right and left lobes of the fetal liver are surrounded by different microenvironments. The right and left lobes of the fetal liver are perfused by vascular systems carrying different concentrations of oxygen and constitute distinct functional units. The aim of this study was to assess the expression of the phenobarbital-inducible cytochrome P-450 b,e genes in hepatocytes of the right and left fetal liver lobes in mice. Northern-blot analysis using [32P]cDNAs and quantitative… CONTINUE READING