Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.

@article{Yang2007CytochromePE,
  title={Cytochrome P-450 epoxygenases protect endothelial cells from apoptosis induced by tumor necrosis factor-alpha via MAPK and PI3K/Akt signaling pathways.},
  author={Shilin Yang and Li Lin and Jianjiao Chen and Craig R. Lee and John Matthew Seubert and Yanli Wang and Hong Wang and Zhong-Ren Chao and De-ding Tao and Jian-ping Gong and Zai-ying Lu and Dao Wen Wang and Darryl C. Zeldin},
  journal={American journal of physiology. Heart and circulatory physiology},
  year={2007},
  volume={293 1},
  pages={
          H142-51
        }
}
Endothelial cells play a vital role in the maintenance of cardiovascular homeostasis. Epoxyeicosatrienoic acids (EETs), cytochrome P-450 (CYP) epoxygenase metabolites of arachidonic acid in endothelial cells, possess potent and diverse biological effects within the vasculature. We evaluated the effects of overexpression of CYP epoxygenases on tumor necrosis factor-alpha (TNF-alpha)-induced apoptosis in bovine aortic endothelial cells. CYP epoxygenase overexpression significantly increased… CONTINUE READING

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