Corpus ID: 19055218

Cytochrome P-450 difference spectra. Type II interactions in insecticide-resistant and -susceptible houseflies.

@article{Kulkarni1974CytochromePD,
  title={Cytochrome P-450 difference spectra. Type II interactions in insecticide-resistant and -susceptible houseflies.},
  author={A. Kulkarni and R. Mailman and R. Baker and E. Hodgson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1974},
  volume={2 3},
  pages={
          309-20
        }
}
The relationship between chemical structure and the difference spectra obtained with microsomes from the abdomens of insecticide-susceptible and -resistant houseflies was examined. The presence of a "sterically accessible" nitrogen atom with a pair of nonbonded electrons or an accessible oxygen atom in certain configurations appears to be of primary importance in the formation of type II difference spectra. However, factors such as steric hindrance and electronic configuration determine the… Expand
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