Corpus ID: 1865672

Cytochrome P-450 difference spectra: effect of chemical structure on type II spectra in mouse hepatic microsomes.

@article{Mailman1974CytochromePD,
  title={Cytochrome P-450 difference spectra: effect of chemical structure on type II spectra in mouse hepatic microsomes.},
  author={R. Mailman and A. Kulkarni and R. Baker and E. Hodgson},
  journal={Drug metabolism and disposition: the biological fate of chemicals},
  year={1974},
  volume={2 3},
  pages={
          301-8
        }
}
A comprehensive study of the relationship between chemical structure and binding was made with mouse hepatic microsomes. The generally reported type II spectrum (peak 424-435 nm, trough 390-410 nm) is correlated with the presence of a nitrogen atom in which sp 2 or sp 3 nonbonded electrons are "sterically accessible." Structural series showed that as substituents are placed closer to this nitrogen, spectral size is either reduced or eliminated. Other nucleophilic atoms with relatively free… Expand
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