Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.

@article{Falck1990CytochromePO,
  title={Cytochrome P-450-dependent oxidation of arachidonic acid to 16-, 17-, and 18-hydroxyeicosatetraenoic acids.},
  author={John R Falck and S Lumin and I. G. Blair and Eric Dishman and M. Virginia Mart{\'i}n and David J Waxman and F Peter Guengerich and J. Capdevila},
  journal={The Journal of biological chemistry},
  year={1990},
  volume={265 18},
  pages={10244-9}
}
Incubation of rat liver microsomal fractions with arachidonic acid in the presence of NADPH results in the formation of three novel monohydroxylated fatty acid metabolites. Utilizing chromatographic and mass spectral techniques, these metabolites have been identified as 16-, 17-, and 18-hydroxyeicosatetraenoic acids. The NADPH-dependent microsomal metabolism of arachidonic acid to 16-, 17-, 18-, and 19-hydroxyeicosatetraenoic acids is induced after animal treatment with beta-naphthoflavone… CONTINUE READING