Cytochrome P-450 and the metabolism of vinyl chloride.

Abstract

The oxidation of vinyl chloride to non-volatile products is dependent on NADPH and microsomal enzymes. The addition of vinyl chloride to microsomes causes a Type 1 spectra shift, similar to that seen for phenobarbital [11[ which indicates the direct involvement of a cytochrome P-450 species; this difference spectrum is characteristic of substrate binding to this type of enzyme. A glutathione conjugate is probably formed, perhaps via a reactive intermediate.

Cite this paper

@article{Salmon1976CytochromePA, title={Cytochrome P-450 and the metabolism of vinyl chloride.}, author={Andrew Salmon}, journal={Cancer letters}, year={1976}, volume={2 2}, pages={109-13} }