Cytochrome P 450 Enzymes in Vascular Homeostasis

  title={Cytochrome P 450 Enzymes in Vascular Homeostasis},
  author={Ingrid Fleming},
Since the initial reports that renal cytochrome P450 (CYP) enzymes can metabolize arachidonic acid to substances which affect arterial tone, it has become increasingly clear that CYP enzymes expressed within the cardiovascular system play a crucial role in the modulation of vascular homeostasis. There is strong evidence suggesting that the activation of a CYP epoxygenase in endothelial cells is an essential step in nitric oxide and prostacyclinindependent vasodilatation of several vascular beds… CONTINUE READING