Cytochrome P-450 3A4: regulation and role in drug metabolism.

@article{Guengerich1999CytochromeP3,
  title={Cytochrome P-450 3A4: regulation and role in drug metabolism.},
  author={F Peter Guengerich},
  journal={Annual review of pharmacology and toxicology},
  year={1999},
  volume={39},
  pages={1-17}
}
Cytochrome P-450 (P-450) 3A4 is the most abundant P-450 expressed in human liver and small intestine. P-450 3A4 contributes to the metabolism of approximately half the drugs in use today, and variations in its catalytic activity are important in issues of bioavailability and drug-drug interactions. The gene is known to be inducible by barbiturates, glucocorticoids, and rifampicin in humans and in isolated hepatocytes, although the mechanism remains unclear. The 5'-untranslated region includes… CONTINUE READING
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