Cytochrome P 450 3 A 4 mRNA Is a More Reliable Marker than CYP 3 A 4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes

@inproceedings{Fahmi2010CytochromeP4,
  title={Cytochrome P 450 3 A 4 mRNA Is a More Reliable Marker than CYP 3 A 4 Activity for Detecting Pregnane X Receptor-Activated Induction of Drug-Metabolizing Enzymes},
  author={Odette A. Fahmi and Mary Kish and Sherri E Boldt and R Scott Obach},
  year={2010}
}
Induction of cytochrome P450 (P450) activity in the clinic can result in therapeutic failure such as tissue rejection in transplant patients or unwanted pregnancy, among others. CYP3A4 is by far the most abundant isoform and is responsible for the majority of P450related metabolism of all marketed drugs. However, it is of importance to understand the significance of induction mediated through other P450 enzymes. The objective of this investigation was to evaluate several known inducers in vitro… CONTINUE READING
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