Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.

  title={Cytochrome P-450 1A1 gene polymorphisms and risk of breast cancer: a HuGE review.},
  author={Lindsey F. Masson and Linda Sharp and Seonaidh C. Cotton and Julian Little},
  journal={American journal of epidemiology},
  volume={161 10},
Cytochrome P-450 (CYP) 1A1 plays a key role in phase I metabolism of polycyclic aromatic hydrocarbons and in estrogen metabolism. It is expressed predominantly in extrahepatic tissues, including the breast. Four CYP1A1 gene polymorphisms (3801T --> C, Ile462Val, 3205T --> C, and Thr461Asp) have been studied in relation to breast cancer. The 3801C variant is more common than the Val variant. Both variants occur more frequently in Asians than in White populations. The 3205T --> C polymorphism has… CONTINUE READING


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