Cytochemical localization of hyaluronic acid in human synovium with special reference to its possible process of degradation.

@article{Asari1995CytochemicalLO,
  title={Cytochemical localization of hyaluronic acid in human synovium with special reference to its possible process of degradation.},
  author={Akira A Asari and Shinichi Kuriyama and Eiki Kominami and Yasuo Uchiyama},
  journal={Archives of histology and cytology},
  year={1995},
  volume={58 1},
  pages={65-76}
}
Fibroblast-like type B cells are known to produce hyaluronic acid (HA), but the process of its degradation remains unknown. In order to examine the possible route for the degradation of HA in normal human synovium, histochemical and immunohistochemical techniques were applied to the synovial tissue, using biotinylated HA binding region (HABR) and antibodies against CD44 and cathepsin B. Reaction products for HA and CD44 were detected on the cell surface of all synovial lining cells, while half… CONTINUE READING