Cytochemical bioassay of circulating concentrations of rat parathyroid hormone: application to a study of age and sex.

@article{Peng1986CytochemicalBO,
  title={Cytochemical bioassay of circulating concentrations of rat parathyroid hormone: application to a study of age and sex.},
  author={Thomas C. C. Peng and Sanford C. Garner and Philip F. Hirsch and James T Posillico},
  journal={Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research},
  year={1986},
  volume={1 4},
  pages={
          351-7
        }
}
We have found that the cytochemical bioassay (CBA) method, originally developed to measure circulating levels of biologically active parathyroid hormone (bioPTH) in humans, also can measure endogenous concentrations of PTH in rats. Therefore, we have applied this assay method to examine the relationships between age and sex and the circulating levels of bioPTH, calcium, and phosphorus in Fischer rats. The concentration of bioPTH increased in both males and females from 5 to 15 months of age (p… CONTINUE READING