Cytochemical Alterations in the Rat Retina by LPS Administration

  title={Cytochemical Alterations in the Rat Retina by LPS Administration},
  author={Soyong Jang and Jae-Hyung Lee and Kyu-Ryong Choi and Donghyun Kim and Hwan-Soo Yoo and Seikwan Oh},
  journal={Neurochemical Research},
LPS-induced inflammation and changes in protein phosphorylation and the JAK-STAT pathway accompanying glial activation after LPS treatment, were followed by analyzing secreted proinflammatory cytokine levels. The administration of LPS caused tyrosine phosphorylation of STAT3 in retinae and induced glial fibrillary acidic protein. (GFAP) from the nerve fiber layer to the ganglion cell layer. Our results suggest that the LPS-induced activation of the JAK2/STAT3 signaling pathway may play a key… CONTINUE READING


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